Dr. Cabot, a respected cell biologist and lipid biochemist, has published extensively on the development and reversal of multidrug resistance in cancer patients. His investigations of tumor resistance to chemotherapy were acknowledged by the American Cancer Society’s Science Writer’s Award (1999). Dr. Cabot is also credited with pioneering work on pivotal second messengers that transport and amplify chemical signals for events within a normal or neoplastic cell. He serves on review boards for the National Cancer Institute, the Department of Defense Breast Cancer Research Program, Phillip Morris Foundation, and the Concern Foundation. In collaboration with researchers at the Childrens Hospital Los Angeles, Georgia Institute of Technology, Mayo Clinic and Foundation, Robert Woods Johnson Medical School, the National Cancer Institute, and Novagen Pharmaceuticals, Dr. Cabot is investigating the biology and treatment of female cancers, leukemia, and certain childhood cancers. The National Institutes of Health has awarded funding for Dr. Cabot to study the role of lipids in the development of drug resistance and develop lipid-based approaches that will block a cancer cell’s ability to resist chemotherapeutic agents. Dr. Cabot’s research is also supported by competitive funding awards from the Susan G. Komen Breast Cancer Foundation, the Guenther Foundation, the Department of Defense, the California Cancer Research Program, and local as well as national philanthropic organizations.
Education
- B.S. Western Carolina University, Cullowhee, NC
- M.A. Western Carolina University, Cullowhee, NC
- Ph.D. The Hebrew University, Hadassah Medical School, Jerusalem, Israel
- Damon Runyon-Walter Winchell Postdoctoral Fellow in Cancer Research, Oak Ridge, TN
- Sabbatical, Institut National de la Sante et de la Recherché Medicale, University Hospital Purpan, Toulouse, France
Research InterestChemotherapy resistance, hormone and growth factor signaling, antiestrogens, mechanism of drug action, lipid metabolism
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